(XLS 46 KB) Additional file 6: Additional
Figure 1. Collision induced disassociation fragmentation pattern of ion M+2H 1210.62. The sequence identified by the Mascot engine was LVLGSADGAVYTLAK from protein Rv2138. (PPT 126 KB) References 1. Kaufmann SH: Tuberculosis: back on the immunologists’ agenda. Immunity 2006, 24: 351–357.PubMedCrossRef MK-0457 cell line 2. Zhang M, Gong J, Lin Y, Barnes PF: Growth of virulent and avirulent ABT-263 manufacturer Mycobacterium tuberculosis strains in human macrophages. Infect Immun 1998, 66: 794–799.PubMed 3. Steenken W, Oatway WH, Petroff SA: BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS: III. DISSOCIATION AND PATHOGENICITY OF THE R AND S VARIANTS OF THE HUMAN TUBERCLE BACILLUS (H(37)). J Exp Med 1934, 60: 515–540.PubMedCrossRef 4. McDonough KA, Kress Y, Bloom BR: Pathogenesis of tuberculosis: interaction of Mycobacterium tuberculosis with macrophages. Infect Immun 1993, 61: 2763–2773.PubMed 5. Sharma D, Tyagi JS: The value of comparative genomics in understanding mycobacterial virulence: Mycobacterium tuberculosis H37Ra genome sequencing – a worthwhile endeavour. J Biosci 2007, 32: 185–189.PubMedCrossRef 6. Wei J, Dahl JL, Moulder JW, Roberts EA, O’Gaora P, Young DB, Friedman RL: Identification of a Mycobacterium tuberculosis gene that enhances mycobacterial survival in macrophages.
J Bacteriol 2000, 182: 377–384.PubMedCrossRef 7. Berthet FX, Lagranderie M, Gounon P, Laurent-Winter C, Ensergueix D, Chavarot P, Thouron F, Maranghi E, Pelicic V, Portnoi D, Marchal G, Gicquel B: Attenuation of virulence by disruption of the Mycobacterium tuberculosis erp gene. Science 1998, 282: 759–762.PubMedCrossRef LCL161 8. Pascopella L, Collins FM, Martin JM, Lee MH, Hatfull GF, Stover CK, Bloom BR, Jacobs WR Jr: Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence.
Infect Immun 1994, 62: 1313–1319.PubMed 9. Zheng H, Lu L, Wang B, Pu S, Zhang X, Zhu G, Shi W, Zhang L, Wang Dipeptidyl peptidase H, Wang S, Zhao G, Zhang Y: Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv. PLoS ONE 2008, 3: e2375.PubMedCrossRef 10. Gao Q, Kripke K, Arinc Z, Voskuil M, Small P: Comparative expression studies of a complex phenotype: cord formation in Mycobacterium tuberculosis. Tuberculosis (Edinb) 2004, 84: 188–196.CrossRef 11. De souza GA, Fortuin S, Aguilar D, Pando RH, McEvoy CR, van Helden PD, Koehler CJ, Thiede B, Warren RM, Wiker HG: Using a label-free proteomic method to identify differentially abundant proteins in closely related hypo- and hyper-virulent clinical Mycobacterium tuberculosis Beijing isolates. Mol Cell Proteomics 2010, 11: 2414–23. 12. Florczyk MA, McCue LA, Stack RF, Hauer CR, McDonough KA: Identification and characterization of mycobacterial proteins differentially expressed under standing and shaking culture conditions, including Rv2623 from a novel class of putative ATP-binding proteins.