(XLS 33 KB) Additional file 3: Table S2. Larval mortality to bacterial cell-derived compounds in the absence of B. thuringiensis. (XLS 18 KB) Additional file 4: Table S3. Summary of the log-rank statistics of survival of third-instar gypsy moth larvae following ingestion of B. thuringiensis toxin and various concentrations of three COX inhibitors. (XLS 20 KB) References 1. Artis D: Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat Rev Immunol 2008, 8:411–420.PubMedCrossRef
2. McCracken VJ, Lorenz RG: The gastrointestinal ecosystem: a precarious alliance among Fostamatinib chemical structure epithelium, immunity and microbiota. Cell Microbiol 2001, 3:1–11.PubMedCrossRef 3. Collier-Hyams LS, Neish AS: Innate immune relationship between commensal flora and the mammalian intestinal epithelium. Cell Mol Life Sci 2005, 62:1339–1348.PubMedCrossRef 4. Sansonetti PJ: War and peace at mucosal surfaces. Nat Rev Immunol 2004, 4:953–964.PubMedCrossRef 5. Müller CA, Autenrieth IB, Peschel A: Innate defenses of the intestinal epithelial barrier. Cell Mol Life Sci 2005, 62:1297–1307.PubMedCrossRef 6. Stecher B, Hardt WD: The role of microbiota Selleckchem Talazoparib in infectious disease. Trends Microbiol 2008, 16:107–114.PubMedCrossRef 7. Kaur T, Ganguly NK: Modulation of gut physiology through
enteric toxins. Mol Cell Biochem 2003, 253:15–19.PubMedCrossRef 8. Heermann R, Fuchs TM: Comparative analysis of the Photorhabdus luminescens and the Yersinia enterocolitica genomes: uncovering candidate genes involved in insect pathogenicity. BMC Genomics 2008, 9:40.PubMedCrossRef 9. Vallet-Gely I, Lemaitre B, Boccard F: Bacterial strategies to overcome insect defenses. Nat Rev Microbiol 2008, 6:302–313.PubMedCrossRef
10. Gonzalez MR, Bischofberger M, Pernot L, Goot FG, Frêche B: Bacterial pore-forming toxins: the (w)hole story? Cell Mol Life Sci 2008, 65:493–507.PubMedCrossRef 11. Uzzau S, Fasano A: Cross-talk between enteric pathogens and the intestine. Cell Microbiol 2000, 2:83–89.PubMedCrossRef 12. Schnepf HE, Crickmore N, Van Rie J, Lereclus D, Baum J, Feitelson J, Zeigler DR, Dean DH: Bacillus thuringiensis and its pesticidal crystal proteins. Microbiol Mol Rebamipide Biol Rev 1998, 62:775–806.PubMed 13. Gill SS, Cowles EA, Pietrantonio PV: The mode of action of Bacillus thuringiensis endotoxins. Annu Rev Entomol 1992, 37:615–636.PubMedCrossRef 14. Knowles BH: Mechanism of action of Bacillus thuringiensis insecticidal delta-endotoxins. Adv Insect Physiol 1994, 24:275–308.CrossRef 15. Pigott CR, Ellar DJ: Role of receptors in Bacillus thuringiensis crystal toxin activity. Microbiol Mol Biol R 2007, 71:255–281.CrossRef 16. Fast PG, Angus TA: Effects of parasporal inclusions of Bacillus thuringiensis var. sotto Ishiwata on the permeability of the gut wall of Bombyx mori (Linnaeus) larvae. J Invertebr Pathol 1965, 20:29–32.PubMedCrossRef 17. Angus TA: A bacterial toxin paralysing silkworm larvae. Nature 1954, 173:545–546.