Who undertakes IPI-145 datasheet medicines reconciliation? Where participating Trusts had an approved medicines reconciliation policy, doctors were the professional group most frequently cited as having the lead role in ensuring that

reconciliation took place. Local reflection in some Trusts may have led to increased awareness of the responsibilities of doctors with respect to medicines reconciliation and the establishment Inhibitors,research,lifescience,medical of systems to facilitate the transfer of information between primary and secondary care. However, we found that activity related to medicines reconciliation was usually undertaken by pharmacy staff, and their relative contribution increased markedly between baseline and re-audit. This may partly reflect local investment in pharmacy staff, particularly medicines management technicians, to meet the recommendations made by NICE and the NPSA Inhibitors,research,lifescience,medical [National Institute for Health and Clinical Excellence and National Patient Safety Agency, 2007]. In a review of the literature, Karnon and Inhibitors,research,lifescience,medical colleagues

concluded that a structured medicines reconciliation process that is pharmacist or nurse led reduces but does not eliminate errors [Karnon et al. 2009]. These authors also described an alternative system that involved clerical staff faxing requests for information about currently prescribed medicines to GPs. These different approaches have not been directly compared and Inhibitors,research,lifescience,medical so their relative efficacy, and advantages and disadvantages, including sustainability, are unknown. Further, it could be argued that processes that separate medicines reconciliation from the clinical history taking and formulation process that occur when a patient is admitted Inhibitors,research,lifescience,medical to hospital have the potential to de-skill clinical staff, particularly junior doctors.

Measuring medicines reconciliation practice In the re-audit, medicines reconciliation was possible in about 80% of patients, in that two or more sources of information about MYO10 the medication taken prior to admission had been checked. However, it is not possible to know the proportion of these patients for whom medicines were appropriately reconciled. For example, it is possible that not all relevant sources were checked for a given patient: a patient may be prescribed medication through a specialist hospital clinic or take herbal medicines supplied by family members. Conversely, according to our definition, medicines reconciliation was not possible in around one in five patients because only one or no source of information about the medicines being taken was checked. However, a legitimate exception to this may be a patient admitted from a care home where medicines were administered by the staff.