We assume that the crystals are solids formed in an aqueous environment, however, we leave open questions as to whether they are crystals of some mineral of direct biological relevance (such as amino acids), or whether they are some other material, which after growing, will later provide a chirally selective surface for biomolecules to crystallise PF299 in vivo on, or be a catalyst for chiral polymerisation to occur. Following Darwin’s (1871) “warm little pond”, an attractive scenario might

be a tidal rock pool, where waves agitating pebbles provide the energetic input for grinding. Taking more account of recent work, a more likely place is a suboceanic hydrothermal vent where the rapid convection of hot water impels growing nucleii into the vent’s rough walls as well as breaking particles off the walls and entraining them into the fluid flow, simultaneously grinding any growing crystals. Crenigacestat In “The BD Model with Dimer Interactions

and an Amorphous Metastable Phase” we propose a detailed microscopic model of the nucleation and crystal growth of several species simultaneously. This has the form of a generalised Becker–Döring Bucladesine cost System of equations (1935). Due to the complexity of the model we immediately simplify it, making assumptions on the rate coefficients. Furthermore, to elucidate those processes which are responsible for homochiralisation, we remove some processes completely so as to obtain a simple system of ordinary differential equations which can be analysed theoretically. The simplest model which might be expected to show homochiralisation is one which has small and large clusters of each handedness. Such a truncated model is considered in “The Truncation at Tetramers” wherein it is shown that such a model might lead to amplification of enantiomeric exess in the short time, but that in the long-time limit, only the racemic state can be approached. This model Acetophenone has the structure akin to that of Saito and Hyuga (2005) truncated at the tetramer level. Hence, in “The Truncation at Hexamers” we consider a more complex model with a cut-off at larger

sizes (one can think of small, medium, and large clusters of each handedness). Such a model has a similar structure to the hexamer truncation analysed by Saito and Hyuga (2005). We find that such a model does allow a final steady-state in which one chirality dominates the system and the other is present only in vanishingly small amounts. However, as discussed earlier, there may be subtle effects whereby it is not just the number of crystals of each type that is important to the effect, but a combination of size and number of each handedness of crystal that is important to the evolution of the process. Hence, in “New Simplifications of the System” we introduce an alternative reduction of the system of governing equations.