This was done more than 1 month before leaving by 47.5% of the responders; 25.1% started preparing 2 weeks to 1 month before departure, 15.7% did so 1 to 2 weeks in advance, and 11.6% did so less than 1 week before leaving. Of those who had not sought health information, the majority stated that they already knew what to do. The most common sources since 2004 for travel health advice to high-risk destinations were the travel clinic or

public health service (66.4%) followed by general practitioner (GP) or family doctor in 21.3% of the respondents. For low-to-intermediate-risk destinations the travel clinic Proteasome purification or public health service was consulted in 53.2% of the respondents, whereas the GP or family doctor was consulted in 27.8% of the cases. In the 2002 and 2003 questionnaires there was no item concerning source of advice. There were no significant trends over the LGK-974 ic50 years in the proportion of travelers to high-risk destinations seeking travel

health advice (p = 0.315). In contrast, trend analyses in travelers to low-to-intermediate-risk destinations showed a decrease over the years in the proportion of travelers seeking travel health advice (p = 0.0005). The group of older adult travelers comprised 439 respondents. Of them, 365 (83.1%) traveled to a high-risk destination. The group of last-minute travelers comprised 545 respondents; 474 (87.0%) of them traveled to a high-risk destination. Of all respondents, 869 respondents traveled alone and were classified as solo travelers; 650 (74.8%) of them Cetuximab traveled to a high-risk destination. The group of business travelers consisted of 453 individuals of whom 330 (72.8%) traveled to destinations rated as a high risk for hepatitis A. The group of VFRs consisted of 521 respondents; 390 (74.9%) of them traveled to a high-risk destination (Table 1). Older adult travelers to either high-risk (p = 0.076) or low-to-intermediate-risk destinations (p = 0.434) did

not better prepare their vacation than younger-aged travelers to the same risk destination. Older adult travelers visited high-risk destinations more frequently (Table 1). The risk perception and protection rate of older adult travelers to either high-risk or low-to-intermediate-risk destinations was comparable to that of younger travelers (Table 2). Older adult travelers, however, had less intended risk-seeking behavior than younger travelers, irrespective of the hepatitis A risk at the planned destination. As a consequence, as shown in Table 3, the composite risk estimate of KAP of older adult travelers suggested a slight reduction of relative risk for hepatitis A. Solo travelers to either high- (p < 0.001) or low-risk destinations (p < 0.001) had less preparation for their travel than non-solo travelers to the same risk destination. Solo travelers traveled more frequently to low-to-intermediate-risk destinations than to high-risk destinations (Table 1).