The total effective rates of abdominal pain were 74.61% and 45.36% (per protocol analysis, PP), 69.57% and 42.35% (intention to treat analysis, ITT), diarrhea NVP-BGJ398 clinical trial were 79.79% and 57.92% (PP), 74.40% and 54.08% (ITT), total signs were 91.19% and 68.85% (PP), 85.02% and 64.29% (ITT) in the study and the control respectively (P < 0.01). The incident rates of adverse drug reaction were 10.36% and 1.09% in the study group and the

control respectively (P < 0.01). Conclusion: There are significantly improved symptoms of depression and anxiety, abdominal pain and diarrhea of patients with IBS-D treated by venlafaxine hydrochloride sustained release table and pinaverium bromid, and the total effective rate are higher and the

adverse drug reaction is lower. Key Word(s): 1. IBS; 2. Venlafaxine; 3. Anxiety; 4. Depression; Presenting Author: OLEG KNYAZEV Additional Authors: ASFOLD PARFENOV, IRINA RUCHKINA, PETER SHCHERBAKOV, LEONID LAZEBNIK, ANATOLIY KONOPLYANNIKOV Corresponding Author: OLEG KNYAZEV Objective: Crohn’s disease www.selleckchem.com/products/yap-tead-inhibitor-1-peptide-17.html (CD) is a chronic inflammatory disease of the gastrointestinal tract with recurrent nature of the flow. The frequency of exacerbations is approximately 20–25% at 1 year and 75% for 3 years. If the remission lasted less than 12 months, there is a 65% chance that the aggravation comes in the next 18 months. For the duration of remission for 12 months or more the likelihood of an explosion in the next 18 months is reduced to 20%. Aim. To evaluate the influence of culture of allogeneic mesenchymal stromal cells (MSCs) of bone marrow for the duration of remission in patients with refractory CD. Methods: The first group of patients with CD (n = 30) received MSCs, the dose of prednisone

was not more than 20 mg/day. The second group of patients (n = 30) received standard anti-inflammatory drug therapy of 5-aminosalicylic acid (5-ASA) and glucocorticosteroids (GCS). Age of patients ranged from 19 to 49 years (Me-36 years). The disease was of moderate and high activity, length of damage – ileokolit, ileitis and colitis, the observation time ranged from 42 to 68 months. Clinical activity was assessed by the Crohn’s disease activity index (CDAI). 上海皓元 The culture of allogeneic MSCs injected drip at 2.5 million per 1 kg of body weight (0-1-26 weeks). Results: CDAI in the 1-st group was 242,6 ± 11,7 points, in the 2-nd 240,9 ± 12,9 points (p = 0,83), CRP levels in 1-st group was 29,3 ± 6.4 mg/l, the 2-nd – 27,8 ± 4,8 (p = 0,47). After 1 year of follow-CDAI in 1-st group was 70,0 ± 11,0 points, in the 2-nd – 133,8 ± 22,2 points (p < 0,001), CRP levels in 1-st group was 6,36 ± 1,5 mg/l, in the 2-nd – 12,2 ± 2,9 (p < 0,001). After 2 years CDAI 1-st group was 99,6 ± 19,3 points, in the 2-nd – 147,1 ± 22,1 points (p < 0,001), CRP levels in 1-st group was 16.0 ± 6,0 mg/l, in the 2-nd – 18,8 ± 4,4 (p = 0,156).