The incidences of mammary
adenocarcinoma and pituitary anterior adenoma were higher than those of other tumors. The present results showed that the same tumors as reported in aged rats could also develop in younger rats. (DOI: 10.1293/tox.24.37: J Toxicol Pathol 2011 24: 37-40)”
“Purpose: To develop a reverse phase ultra-performance liquid chromatographic (RP-UPLC) method for the estimation of rabeprazole sodium in tablet formulations.
Methods: Chromatographic separation was achieved on a Waters Acquity BEH C(18) (50 x 2.1 mm, particle size 1.7 mu m) column using an isocratic method with mobile phase composed of acetonitrile and phosphate buffer (pH 7.4) in the ratio of 35: 65 (v/v). The flow rate was 0.4 ml/min, temperature of the column was maintained at ambient, injection volume was 5 mu L and detection was made at 280 nm. The run time was as short as 2 min. Comparison of system performance with conventional FK228 research buy HPLC was made with respect to analysis time, efficiency and sensitivity.
Results: The developed method was linear for rabeprazole sodium from 0.03 – 30 mu g/ml and the linear regression obtained was > 0.999. Precision, evaluated by intra-and inter-day assay,s had relative standard deviation (R. S. D) values within 1.5 %. Recovery
data were in the range 98.0 – 101.5 % with R.S.D. values < 1.5 click here %.
Conclusion: The method is precise, accurate, linear, robust and fast. The short retention time of 1.49 min allows the analysis of a large number of samples in a short period of time and, therefore, should be cost-effective for routine analysis in the pharmaceutical industry.”
“Replacing missing bone or adding
mass to existing bone is often essential to the success of a dental implant. A large variety of graft materials have been used for maxillary and mandibular atrophy. To date, there has been no graft material which can be regarded as completely satisfactory. Our experience with freshly isolated autologous bone marrow-derived mononuclear cells find more combined with beta-tricalcium phosphate for augmentation of the extremely atrophied maxilla is presented. The techniques are based on stimulation of natural events continuously present in living bone, that is, the process of bone remodeling. The property of the mixture material for bone augmentation to place dental implant was discussed.”
“Objective. The aims were (1) to search the scientific literature from 2007 to 2012 for guidelines and new studies on the dental management of patients using oral antithrombotic medication; (2) to summarize the articles’ evidence and recommendations; and (3) to propose an updated clinical practice guideline for general dentists.
Study Design. A systematic literature search in MEDLINE, Embase, and the Guideline websites, from October 2007 to October 2012, produced articles that were critically evaluated.
Results.