The FD is dependant on the external moments developed by gravity and inertia at each of the joints and the internal moments required to be produced by the muscles crossing that joint in order to counteract the external moment generated

during a functional task (Samuel, Rowe, Hood, & Nicol, 2011). Conventionally, the loading on the muscle group has been evaluated by comparing the peak external moment in a functional task with the maximum muscle strength. However this method is flawed because the peak external moment may occur at a joint angle different to the position of maximal ABT 263 muscle strength and muscle strength is highly dependent on joint angle (Samuel & Rowe, 2009). Hence, in this study we defined “FD” as the muscle moment required at a particular joint angle during a functional task, divided by the maximum isometric muscle strength available at the joint

angle (expressed as a percentage) (Rowe, Samuel, & Hood, 2005). Therefore, the aim of the present study was to characterize the level of FD placed on the hip and knee joints during gait, CR, CSt and SA and SD in older adults. Ethical approval was obtained from the Ethics Committee of the Bioengineering Unit, University of Strathclyde. All participants provided written informed consent prior to participation in the study. Eighty-four healthy older adults aged 60–88 years (mean age 73.2 years (SD 7.3); height 1.66 m (SD 0.1); body mass 73.7 kg (SD 13.1)); 41 males and 43 females were recruited through posters placed in older adult organizations in the Greater Glasgow area, Stirlingshire and Ayrshire in Scotland, Pictilisib purchase UK. Participants were categorized into three sub-groups (60–69 years, 70–79 years and 80 years and over) based on their age and were from a wide range of social, economic and educational backgrounds as reported through an initial screening questionnaire. The inclusion and exclusion

criteria published previously (Greig et al., 1994) were adopted for inclusion of older adults. Those with neurological conditions, musculoskeletal disease or systemic disorders affecting multiple joints such as Rheumatoid Arthritis were excluded from the study. Participants attended the Biomechanics Laboratory at the University of Strathclyde for two, 2-h sessions, one Calpain for muscle strength tests and one for whole body biomechanical assessment. A torque dynamometer attached to a purpose-built plinth was utilized to measure isometric muscle moments. The device consisted of a strain-gauged metal bar referred to as the transducer attached to a circular indexing wheel. The transducer and indexing wheel were attached to an aluminum base which was secured to the frame of a custom-built plinth. The output from the transducer was amplified using a strain-gauge amplifier and was input into a 16-channel analog to digital data collection system, housed inside a PC computer.