Radioisotopes Tc-94m and Tc-97m were not detected in the irradiated Mo-100 targets due to their low activities and measurement conditions: on the other hand we detected small amounts of the short-lived positron emitter Tc-93 (T-1/2=2.75 h). In addition to Tc-99m and trace amounts of the various Tc isotopes, significant activities of Nb-96, Nb-97 and Mo-99 were detected in the irradiated Mo-100 targets.
Conclusions:
Verubecestat Radioisotope formation during the proton irradiation of Mo targets prepared from different, enriched stable Mo isotopes provides a useful data base to predict the presence of Tc radionuclidic impurities in Tc-99m derived from proton irradiated Mo-100 targets of known isotopic composition. The longer-lived Tc isotopes including Tc-94 (T-1/2=4.883 h), Tc-95 (T-1/2=20.0 h), Tc-95m (T-1/2=61 d), Tc96m+g (T-1/2=4.24 d) and Tc-97m (T-1/2=90 d) are of particular concern
since they may affect the dosimetry in clinical applications. Our data demonstrate that cyclotron production of Tc-99m, using highly enriched Mo-100 targets and 19-24 MeV incident proton energy, will result in a product of acceptable radionuclidic purity for applications in nuclear medicine. (C) 2012 Elsevier Inc. All rights reserved.”
“Objective: We used a population-based data set to assess the association between the extent of pulmonary resection for bronchoalveolar this website carcinoma and survival. The reports thus far have been limited to small, institutional series.
Methods: Using the Surveillance, Epidemiology, and End Results database (1988-2007), we identified patients with bronchoalveolar carcinoma who had undergone wedge resection, segmentectomy, or lobectomy. The bronchoalveolar carcinoma histologic findings were mucinous, nonmucinous, mixed, not otherwise specified, and alveolar carcinoma.
To adjust for potential confounders, we used a Cox proportional hazards regression model.
Results: A total of 6810 patients met the inclusion criteria. Compared with the sublobar resections (wedge PS-341 solubility dmso resections and segmentectomies), lobectomy conferred superior 5-year overall (59.5% vs 43.9%) and cancer-specific (67.1% vs 53.1%) survival (P < .0001). After adjusting for potential confounding patient and tumor characteristics, we found that patients who underwent an anatomic resection had significantly better overall (segmentectomy: hazard ratio, 0.59; 95% confidence interval, 0.43-0.81; lobectomy: hazard ratio, 0.50; 95% confidence interval, 0.44-0.57) and cancer-specific (segmentectomy: hazard ratio, 0.51; 95% confidence interval, 0.34-0.75; lobectomy: hazard ratio, 0.46; 95% confidence interval, 0.40-0.53) survival compared with patients who underwent wedge resection. Additionally, gender, race, tumor size, and degree of tumor de-differentiation were negative prognostic factors.