L.C.O. developed the analysis plan and performed all the statistical evaluations and models. B.G., R.I.M. and J.P. developed the instruments for data collection and the study database. J.S.M., J.S., B.C., O.G.M. and M.B.L. contributed to data collection and verification. W.H.B., L.C.O., M.H.L., A.L.R. and B.G. contributed to the process of writing the manuscript. J.S.M., J.S., M.B.L. and O.G.M. participated in the correction of the final version of the manuscript. “
“Chronic kidney
disease (CKD) is common in HIV-infected individuals, and is associated with mortality in both the HIV-infected and general populations. Urinary markers of tubular injury have been associated with future kidney disease risk, but associations with mortality are unknown. Selleck PF 2341066 We evaluated the associations of urinary interleukin-18 (IL-18), liver fatty acid binding protein
(L-FABP), kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL) and the albumin-to-creatinine ratio (ACR) with 10-year, all-cause death in 908 HIV-infected women. Serum cystatin C was used to estimate the glomerular filtration rate (eGFRcys). There were 201 deaths during 9269 person-years of follow-up. After demographic adjustment, compared with the lowest tertile, the highest tertiles of IL-18 [hazard ratio (HR) 2.54; 95% confidence interval (CI) 1.75–3.68], KIM-1 (HR 2.04; 95% CI 1.44–2.89), NGAL (HR 1.50; 95% CI 1.05–2.14) and ACR (HR 1.63; 95% CI 1.13–2.36) were associated with buy Everolimus higher mortality. After multivariable adjustment including adjustment for eGFRcys, only the highest tertiles of IL-18 (HR 1.88; 95% CI 1.29–2.74) and ACR (HR 1.46; 95% CI 1.01–2.12) remained independently associated with mortality. Findings for KIM-1 were borderline (HR 1.41; 95% CI 0.99–2.02). We found a J-shaped association between L-FABP and mortality. Compared with persons in
the lowest tertile, the HR for the middle tertile of L-FABP was 0.67 (95% CI 0.46–0.98) after adjustment. Associations were stronger when IL-18, ACR and L-FABP were simultaneously included in models. Among HIV-infected Sclareol women, some urinary markers of tubular injury are associated with mortality risk, independently of eGFRcys and ACR. These markers represent potential tools with which to identify early kidney injury in persons with HIV infection. “
“Improvements in neurocognitive (NC) function have been associated with commencing antiretroviral therapy in HIV-infected subjects. However, the dynamics of such improvements are poorly understood. We assessed changes in NC function via a validated computerized battery (CogState™, Melbourne, Victoria, Australia) at baseline and after 24 and 48 weeks in a subset of therapy-naïve neuro-asymptomatic HIV-infected subjects, randomized to commence three different antiretroviral regimens.