Pevonedistat in vitro Factors influencing the prevalence of vertebral fractures are reported in Table 2. Regarding

sex distribution, the prevalence of vertebral fractures was higher in men than in women, and also the percentage in which such fractures were unknown was higher in men (75% in men and 65% in women). Limiting these data to moderate and severe fractures only, the prevalence in men was 15% (131/851) and 12% in women (191/1,573). Table 2 Univariate analysis of variables influencing vertebral fracture status Factor Number % of this website total Number with VF Percent p (t test) Sex         <0.0001   Male 851 35.1% 232 27%     Female 1573 64.9% 309 20%   Female menopausal status         <0.0001   Pre 332 21.2% 22 7%     Post 1241 78.8% 287 23%   Visit status         0.31   First 1641 67.7% 376 23%     Follow-up 783 32.3% 165 21%   Osteoporosis suspicion         <0.0001   Primary 662 27.3% 221 33%     Secondary 1762 72.7% 320 18%   Recent low-energy fracture         <0.0001   Yes 570 23.5% 190 33%     No 1854 76.5% 351 19%   Steroid use (ever)         0.006   Yes 960 39.6% 187 20%     No 1464 60.1% Selleck Tariquidar 354 25%   Smoker         0.76

  Yes 593 24.5% 135 23%     No 1831 75.5% 406 22%   Ever previous fracture         <0.0001   Yes 1251 52% 346 28%     No 1173 48% 195 17%   X-spine in last 2 years         <0.0001   Yes 838 35% 276 33%     No 1586 65% 265 17%   Self-reported posture change         <0.0001   Yes 400 17% 174 44%     No 2024 83% 367 18%   X-spine requested with BMD request         <0.0001   Yes 190 41% 66 35%     No 276 59% 54 20%   The age distribution of vertebral Isotretinoin fractures is presented in Table 3. As expected the prevalence of vertebral fractures increases with age and reached approximately 50% in patients older than 70 years. Of interest, the proportion of moderate and severe fractures also increased with age. Further stratifying this for sex the rate of vertebral fractures in men was 10%, 19%, 21%, 28%, 36%, 49%, 50% in the age groups of Table 3, versus 5%,

7%, 11%, 18%, 22%, 47%, 49% in women. Table 3 Age distribution and prevalence of vertebral fractures (VF) Age group N in age group N with VF % with VF % with mild VF only % with moderate or severe VF 11–20 38 2 5.3 5.3 0 21–30 191 14 7.3 5.2 2.1 31–40 275 31 11.2 5.8 5.4 41–50 386 58 15.0 8.5 6.5 51–60 728 155 21.3 9.5 11.8 61–70 508 139 27.4 10.4 17.0 71–80 216 103 47.7 13.0 34.7 81–90 81 39 48.1 11.1 37.0 >90 1 0 – – – Total 2424 541 22.1 8.9 13.3 Other factors that were associated with higher prevalence of vertebral fractures were postmenopausal status of women as compared to premenopausal status, primary osteoporosis vs. secondary osteoporosis, recent low-energy fracture, use of steroids, history of any fracture, patients who underwent spinal radiograph in the last 2 years and self-reported posture change. No difference was found in vertebral fracture prevalence in those who came for a first vs. follow-up visit and in smokers vs. non-smokers.