Disclosures: Guruprasad P. Aithal – Advisory Committees or Review Panels: Aegerion Pharmaceuticals, Abbott, UK, LtD, Falk Pharma; Consulting: Biogen Idec, OTSUKA PHARMACEUTICAL EUROPE LTD, Basilea Pharmaceutica; Speaking and Teaching: Lilly Fernando Bessone – Advisory Committees or Review Panels: Schering Plough, Gilead, Glaxo; Speaking and Teaching: Bristol Myers Squibb, Janssen, Bayer Dominique G. Larrey – Board Membership: ROCHE, MSD, TIBOTEC/JANSSEN, ABBOTT, BOEHRINGER, NVP-LDE225 order BMS, GILEAD; Consulting: BAYER, SANOFI, PFIZER, SERVIER, HELSINN, MMV, BIAL, TEVA; Grant/Research Support: Roche, Boehringer, BMS, GILEAD;

Independent Contractor: ABBOTT Daniel Shouval – Advisory Committees or Review Panels: Scigen; Board Membership: Scigen; Consulting: Scigen The following people have nothing to disclose: Dina Halegoua-De Marzio, Maricruz Vega, Joel Schifter Weber, Raul J. Andrade, Einar Bjornsson, Helgi K. Bjornsson, Maribel Lizarzabal, M. I. Lucena, Inmaculada Medina Cáliz, Edgardo Mengual, Sigurdur Olafsson, Marie-Pierre Ripault, Leonard B. Seeff, Jose Serrano, C. Stephens, Felix Stickel, Victor J. Navarro Background: Drug-induced liver injury (DILI) accounts for approximately 10 percent of all cases of acute hepatitis. Temozolomide (TMZ) is an alkylating, anti-neoplastic agent used for the treatment of refractory anaplastic astrocytoma, glioblastoma multiforme (GBM).

Levetiracetam (LEV) is an established as antiepileptic drug. When administered separately each buy AZD1208 drugs is considered to be relatively safe. however, LEV and TMZ are commonly used together in the treatment of brain malignancies. Aim: To determine the rate

of liver injury due to combination therapy with TMZ and LEV. Methods: We retrospectively compared records of patients with and without Ribose-5-phosphate isomerase the combination of TMZ and LEV in our institution (2007-2013). Data included demographics, liver injury reflected by liver enzymes and patients outcome Results: 32 patients with combination therapy (group A) were compared to 73 age/sex matched patients with monotherapy (group B). Groups were similar in underlying indication for treatment, There were 64 men and 52 women, mean age 53 ±14 vs. 51 ± 19 years (A vs. B, P=NS). Indications for treatment were: Astrocytoma 50. 4% vs. GBM 49. 6% (P=NS), body surface area was 1. 92±0. 2 vs. 1. 82±0. 2 (P=NS comparing group A vs. group B), O6-methylguanine methyltransferase (MGMT) in the brain tissue was 28% vs. 16. 4% (P=0. 2, comparing group A vs. B), no difference in daily dose of LEV 1. 71±0. 6G vs. 1. 82±0. 99G (P=NS) comparing group A vs. B, as for liver injury, the initial levels of liver enzymes were similar between group A and B ( 30 vs. 26 for ALT, 24 vs. 27 for AST, 79 vs. 72 for ALK-P, 62 vs. 68 for GGT and bilirubin levels 6. 41mmol/ml P=NS) but comparing liver enzymes during dual treatment was different with 241 VS. 26. 5 for ALT, 118 vs. 26 for AST, 164 vs. 70 for ALK-P, 228 vs. 62 for GGT and 46 vs. 8. 6 for bilirubin levels P=0.