Conflicts of interest None. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Appendix 1 Table 5 List of ICD-10 CA codes by type of fracture Fracture type ICD 10 codes relating to fracture selleck chemical type Hip S72.0, S72.1, S72.2 Humerus S42.2 Vertebral S22.0, S22.1, S32.0 Wrist S52 with CCI codes Other sites:

 • Femur S72.3, S72.4, S72.7, S72.8, S72.9  • Lower leg (tibia, fibula, ankle, knee, foot) S82.0–S82.9, S92  • Lower arm (radius, ulna) S52 unless wrist above  • Other site (rib, shoulder, arm) S22.3, S42.0, S42.7, S42.8, S42.9  • Other fractures including: S22.2, S22.4,

S22.8, S22.9  • ribs/sternum, clavicle, pelvis, patella, S32.1, S32.3, S32.4, S32.5, S32.7, S32.8  • tibia/fibula, ankle S42.0–42.9 except 42.2, S42.7, S42.8, Galunisertib mouse S42.9 S72.0–72.9 except when “hip/femur” from above Multiple fractures T02.1–T02.9 (or more than 1 of above) References 1. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM et al (2010) 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ 182(17):1864–1873PubMedCrossRef 2. Brown JP, Josse RG (2002) 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 167(10 Suppl):S1–S34PubMed 3. Statistics Canada (2010) Estimates of population, by age group and sex for July 1, Canada, provinces and territories, annual. Table 051–0001

4. Goeree R, O’Brien B, Pettitt D, Cuddy L, Ferraz M, Adachi JD (1996) An assessment of the burden of illness due to osteoporosis in Canada. J Soc Obstet Gynaecol Can 18(Suppl July):15–24 5. Statistics Canada (2011) Consumer Price Index (CPI) Statistics. Table 176–000 6. Canadian Institute for Health Information (2006) Discharge Abstract Database (DAD) Abstracting Manual, 2007–2008 Edition (Ottawa: CIHI, 2006) 7. Canadian Institute for Health Information (2010) National aminophylline Ambulatory Care Reporting System (NACRS), Database Background and General Data Limitations Documentation,, 2007–2008 (Ottawa, Ont.: CIHI, 2008) 8. Canadian Institute for Health Information (2010) National Rehabilitation Reporting System (NRS) Data Quality Documentation 2007–2008 (Ottawa, Ont.: CIHI, 2009) 9. Canadian Institute for Health Information (2010) Home Care Reporting System 10. Canadian Institute for Health Information (2010) Continuing Care Reporting System (CCRS) Specifications Manual, 2009 (Ottawa, Ont.: CIHI, 2008) 11. Intercontinental Marketing Services (IMS) Health Canada (2010) 12. IMS Brogan (2010) Brogan PharmaStat ® Database. Pharmaceutical Market Data 13.