Conclusion: In selected diabetic population, incidence of NDRD was 75% and all patients had type 2 DM. Wide spectrum of different categories of renal diseases in diabetics depend on usual prevalence of renal diseases in general population according to geographical and ethnic characterstics and underlying

diabetes mellitus has no bearing on development of specific type of NDRD. Patients with NDRD had shorter duration of diabetes and lesser prevalence of hypertension.None of the seven clinical and laboratory criteria including absence of diabetic retinopathy, considered GW-572016 molecular weight atypical for a diabetic nephropathy patient, which led to suspicion of underlying NDRD, could strongly predict occurrence of the same. So renal biopsy is the only investigation presently available to make a definitive diagnosis of NDRD. GOPLANI KAMAL R1,2, KASWAN KAMAL K3, GERA DINESH N5, SHAH PANKAJ R5, VANIKAR ARUNA V6, PATEL HIMANSHU V4, GUMBER MANOJ R5, KUTE VIVEK B4, TRIVEDI HARGOVIND L7 1Shalby Hospitals, Ahmedabad; 2Hon.Associate Professor Civil Hospital Ahmedabad; 3Consultant Nephrologist, Narayan Hrudayala, Jaipur, India; 4Assistant Professor Nephrology, IKDRC-ITS,

Ahmedabad India; 5Professor, Dept. of Nephrology, IKDRC-ITS, Ahmedabad; 6Professor, Dept Of Pathology, IKDRC-ITS, Ahmedabad; 7Director, IKDRC-ITS, Ahmedabad Introduction: Rapidly progressive glomerulonephritis(RPGN) is one of the most calamitous conditions in the nephrology where patients can progress from normal renal function to end stage renal failure within weeks. Patients and renal survival is significantly dependent on early proper management. Recognition of proper etiology & extent of pathology mTOR inhibitor by early renal biopsy is essential in advance to decide timely treatment of these patients for proper salvageability. Aim of the study: To study the epidemiology of RPGN

atour centre.To study the response of aggressive treatment modalities like cytotoxic drugs and plasmapharesis. Methods: This is a prospective study of profile of rapidly progressive glomerulonephritis. Cases admitted to our institute between Aug. 2008 to Dec. 2010 were included. Mean follow up duration was 209 +/-135 days.All patients were treated with Steroids+ Cyclophosphamide+/− Megestrol Acetate plasmapharesis. Results: Of total 86 patients mean age 30.23 + 34.16 yrs. Male : Female ratio 1:1.Commonest presenting symptom was oligouria(76.92%) macroscopic hematuria in 86.54%, microscopic hematuria in 86.54%.Mean duration of illness before diagnosis was 21.19 + 35.8 days. Pauciimmune GN was the most common etiology with 24.41% followed by PIGN in 22.09%, Lupus in 17.44%, IgA in 15.11% and MPGN in 12.79%.ANCA negative pauciummune GN was equal in number to ANCA +ve GN. 75% required dialysis on presentation.Complete renal recovery was present in 41.86% while partial renal recovery was present in 30.23%, while 27.90% progressed to end stage renal disease. Plasma exchange was done in 22 patients out of which 12 had renal recovery.