A larger, longitudinal study would better address the overall outcomes of this technique. (C) 2013 Elsevier Ireland Ltd.

All rights reserved.”
“OBJECTIVES: To determine the prevalence of pulmonary tuberculosis (PTB) and associated risk factors among inmates in three major prison settings of Eastern Ethiopia.

DESIGN: Between July and November, 2008, 371 prisoners with a history of cough of >= 2 weeks were screened for PTB using direct GNS-1480 inhibitor smear microscopy and culture. Data were analysed using descriptive statistics and multivariable logistic regression.

RESULTS: Of 371 PTB suspects identified by active screening, 33 (8.9%) were confirmed as smear- or culture-positive PTB. Together with the 11 PTB patients already on treatment, the point prevalence of PTB was 1913 per 100000 (95%CI 1410-2580), about seven times higher than that of the general population. Eleven newly diagnosed PTB patients were sharing a cell with known TB patients. Factors significantly associated with PTB were young learn more age (15-44 years of age) (OR 3.73), urban residence (OR 3.59), having a cough > 4 weeks (OR 3.15), and sharing a cell with a TB patient (OR 3.39) or a prisoner

with chronic cough (OR 4.5).

CONCLUSIONS: The study documented a high prevalence of PTB among Ethiopian prisoners. Socio-demographic and TB management factors were identified to be underlying causes of the high transmission rate and the acquisition of new cases. Active surveillance of TB and implementing prevention and control guidelines are imperative.”
“Objective: The aim of this study was to evaluate Nirogacestat clinical trial the evolution of the immunological and oral clinical conditions of children and adolescents undergoing anticancer treatment for leukemia (ATL).

Methods: Twenty patients aged 3-15 years undergoing chemotherapy seen at a referral center for cancer treatment in the State of Maranhao, Brazil, from 2008 to 2009, were evaluated at baseline (1st). Twenty-two controls were selected in public schools. Oral lesions, caries experience (deft and DMFT), plaque index (PI),

gingival index (GI) and salivary IgA were analyzed. Patients and controls were evaluated after 6 months (2nd). The Shapiro Wilk, Mann-Whitney, Wilkoxon and Spearman correlation tests were carried out (alpha = 5%).

Results: Gingivitis and mucositis were the most frequent manifestations in oral mucosae during the two phases. The mean DMFT index increased from 3.9 +/- 4.2 (1st) to 4.4 +/- 4.3 (2nd) (p = 0.04). The mean deft index was the same in the 1st (1.9 +/- 2.7) and 2nd (1.9 +/- 2.7) evaluation (p = 0.86). The GI also did not vary between assessments: 1st (1.3 +/- 0.4) and 2nd (1.3 +/- 0.3) -(p = 0.12), except on the lingual and distal surfaces, where increased from the 1st to 2nd evaluation (p < 0.01). The PI varied from 0.9 to 1.1, but this difference was not significant (p = 0.48), except for the lingual surface, where increased from 0.6 to 1.0 (p = 0.04).