96 (0.72–1.27)  Useful specialist 0.41 (0.08–2.12)  Useful CME 0.23 (0.05–1.18) Explaining the inheritance pattern Country Selleckchem A-1210477 (reference UK)  France 1.91 (1.26–2.89)  Germany 1.31 (0.87–1.98)  Netherlands 0.91 (0.59–1.38)  Sweden 1.48 (0.98–2.23)

Gender (reference male)  Female 1.05 (0.82–1.35) Age (reference >50)  ≤50 1.44 (1.14–1.83) Years in practice (reference >20)  11–20 1.40 (1.08–1.81)  ≤10 1.23 (0.87–1.74) Highest genetic education (reference none)  Undergraduate 1.48 (1.07–2.04)  During specialist training 1.96 (1.07–3.61)  CME 1.09 (0.71–1.67) Value of genetic education (reference useless)  Useful undergraduate 1.55 (1.17–2.05)  Useful specialist 1.45 (0.37–5.66)  Useful CME 0.84 (0.19–3.65) Explaining the risk to Mr Smith’s children Country (reference UK)  France 2.95 (1.85–4.70)  Germany 1.64 (1.02–2.63)  Netherlands 1.31 (0.81–2.13)  Sweden 1.38 (0.85–2.21) Gender (reference male)  Female 0.64 (0.48–0.84) Age (reference >50) ≤50 1.20 (0.93–1.55) Years in practice (reference >20)  11–20

1.03 (0.78–1.36)  ≤10 0.89 (0.61–1.31) Highest genetic education (reference none)  Undergraduate 1.05 (0.75–1.47)  During specialist training 1.49 (0.79–2.81)  CME 0.89 (0.57–1.40) Value of genetic education (reference useless)  Useful undergraduate 1.50 (1.10–2.05)  Useful specialist training 1.62 (0.38–6.88)  Useful CME 0.56 (0.13–2.43) Giving information about available gene tests Country (reference UK)  France 2.17 (1.30–3.63)  Germany 1.84 (1.10–3.07)  Netherlands 1.27 (0.75–2.16)  Sweden 1.59 (0.95–2.67) Gender (reference male)  Female 0.63 (0.46–0.85) Age Trichostatin A (reference >50)  ≤50 0.69 (0.52–0.91) Years in practice (reference >20)  11–20 0.79 (0.59–1.07)  ≤10 0.56 (0.36–0.88) Highest genetic education Branched chain aminotransferase (reference none)  Undergraduate 0.87 (0.61–1.24)  During specialist training 1.10 (0.56–2.18)  CME 0.73 (0.45–1.19) Value of genetic education (reference useless)  Useful undergraduate 1.48 (1.05–2.09)  Useful specialist training 3.77 (0.44–31.96)  Useful CME

0.73 (0.14–3.77) INCB018424 mw Informing Mr Smith of the implications if no mutation were to be found Country (reference UK)  France 4.01 (1.82–8.80)  Germany 23.97 (11.29–50.87)  Netherlands 7.76 (3.63–16.62)  Sweden 5.58 (2.59–12.03) Gender (reference male)  Female 0.58 (0.43–0.77) Age (reference >50)  ≤50 1.06 (0.82–1.37) Years in practice (reference >20)  11–20 1.02 (0.78–1.35)  ≤10 0.65 (0.43–0.98) Highest genetic education (reference none)  Undergraduate 0.99 (0.71–1.40)  During specialist training 1.53 (0.81–2.88)  CME 1.09 (0.70–1.70) Value of genetic education (reference useless)  Useful undergraduate 1.27 (0.93–1.74)  Useful specialist training 0.68 (0.17–2.69)  Useful CME 0.61 (0.14–2.66) Informing Mr Smith of the implications if a mutation were to be found Country (reference UK)  France 4.46 (1.83–10.89)  Germany 8.51 (3.58–20.20)  Netherlands 3.42 (1.39–8.42)  Sweden 4.64 (1.92–11.21) Gender (reference male)  Female 0.52 (0.36–0.76) Age (reference >50)  ≤50 0.85 (0.61–1.