All subjects received 40 g cocoa powder with 500 mL skim milk/d (C+ M) or only 500 mL skim milk/d (M) for 4 wk. Before and after each intervention period, cellular and serum inflammatory biomarkers related to atherosclerosis were evaluated.
Results: Adherence to the dietary protocol was excellent. No significant changes in the expression of adhesion molecules on T lymphocyte surfaces were found between the C+ M and M groups. However, in monocytes,
the expression of VLA-4, CD40, and CD36 was significantly lower (P = 0.005, 0.028, and 0.001, respectively) after C+ M intake than after M intake. In addition, serum concentrations of the soluble endothelium-derived adhesion molecules P-selectin and intercellular adhesion molecule-1 were significantly lower (both P
= 0.007) after C+ M intake than S3I-201 supplier after M intake.
Conclusions: These results suggest that the intake of cocoa polyphenols may modulate inflammatory mediators in patients at high risk of cardiovascular disease. These antiinflammatory effects may contribute to the overall benefits of cocoa consumption against atherosclerosis. This trial was registered in the Current Controlled Trials at London, International Standard Randomized Controlled Trial Number, at controlled-trials.com NCT-501 molecular weight as ISRCTN75176807. Am J Clin Nutr 2009; 90: 1144-50.”
“Metastatic renal cell carcinoma (mRCC) is a difficult to treat malignancy and currently Sunitinib is a standard of care first-line therapy. A new metastasis during the treatment is considered a sign of drug failure and alternative therapeutic methods should be tried. Here, we report 2 cases of newly diagnosed isolated metastasis during Sunitinib treatment of mRCC patients. Our management plan included local palliative therapy to the lesion followed by recommencing of Sunitinib. This resulted in a good symptomatic relief locally as well as good overall control of the disease.
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“Heteroepitaxial spinel ferrites NiFe(2)O(4) and CoFe(2)O(4) films have been prepared by pulsed laser deposition at various temperatures (175-690 degrees C) under ozone/oxygen pressure of 10 mTorr. Due to enhanced kinetic energy of ablated species at low pressure and enhanced oxidation power of ozone, epitaxy has been achieved at significantly lower temperatures than previously reported. Films grown at temperature below 550 degrees C show a novel growth mode, which we term “”vertical step-flow”" growth mode. Epitaxial spinel ferrite films with atomically flat surface over large areas and enhanced magnetic moment can be routinely obtained. Interestingly, the growth mode is independent of the nature of substrate (spinel MgAl(2)O(4), perovskite SrTiO(3), and rock-salt MgO) and film thickness. The underlying growth mechanism is discussed. (C) 2010 American Institute of Physics. [doi: 10.1063/1.