Physical exam was unremarkable except for an enlarged thyroid gland. Her identical twin sister, who incidentally accompanied her to clinic, also had a previously unidentified goiter. Testing for diabetes was negative. Further laboratory investigation was consistent with Graves’ disease in both girls. Polydipsia is a rare and unusual presenting feature of hyperthyroidism in children.
The evolution of this case highlights the importance of maintaining a high index of suspicion for thyroid Caspase inhibitor disease during childhood.”
“Background: Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes and may operate via impaired glucagon-like peptide 1 secretion, which is stimulated more by fat than by carbohydrate ingestion.
Objective: The objective
was to examine the interaction between TCF7L2 rs7903146 and dietary fat and carbohydrate [high-fat, low-carbohydrate: 40-45% of energy as fat (HF); compared with low-fat, high-carbohydrate: 20-25% of energy as fat (LF)] in obese individuals’ responses to a 10-wk hypoenergetic diet (-600 kcal/d).
Design: European, obese participants (n = 771) were randomly assigned to receive an HF or an LF diet. Body weight, fat mass (FM), fat-free mass (FFM), waist circumference (WC), resting energy expenditure (REE), fasting fat oxidation in percentage of REE (FatOx), homeostasis model assessed insulin release (HOMA-beta), and HOMA-insulin
resistance click here (HOMA-IR) were determined at baseline and after the intervention; 739 individuals were genotyped for rs7903146.
Results: Average weight loss was 6.9 kg with the LF and 6.6 kg with the HF (difference between diets, NS) diet. Among individuals who were homozygous for the Trisk allele, those in the HF diet AZD6244 clinical trial group experienced smaller weight losses (Delta weight) (2.6 kg; P = 0.009; n = 622), smaller Delta FFM(1.6 kg; P = 0.027; n = 609), smaller Delta WC (3.3 cm; P = 0.010; n = 608), and a smaller Delta HOMA-IR (1.3 units; P = 0.004; n = 615) than did the LF diet group. For C allele carriers, there were no differences between the HF and LF diet groups. For the HF diet group, each additional T allele was associated with a reduced loss of FM (0.67 kg; P = 0.019 n = 609). TCF7L2 rs7903146 was not associated with Delta REE, Delta FatOx, Delta HOMA-beta, or dropout.
Conclusion: Our results suggest that obese individuals who are homozygous for the TCF7L2 rs7903146 T risk allele are more sensitive to LF than to HF weight-loss diets. Am J Clin Nutr 2010;91:472-9.”
“Background and Aim: Oxidized low-density lipoprotein (ox-LDL) causes atherosclerosis and endothelial dysfunction. No study up to the present date has examined the relative contribution of all the oxidized components in ox-LDL to inhibition on vascular function.