However, leptin secretion and HPA axis function in elderly persons with other body composition phenotypes is largely unknown.
Methods. Forty-five healthy elderly participants were classified normal lean (NL), sarcopenic (SS), sarcopenic-obese (SO), or obese (00) using dual-energy https://www.selleckchem.com/products/Verteporfin(Visudyne).html x-ray absorptiometry.
Growth hormone (GH), cortisol, and leptin secretion were evaluated during a free-running night, and oral glucocorticoid Suppression test (dexamethasone DEX). Diurnal cortisol secretion was assessed by hourly salivary samples with timed meals. Data were analyzed using cluster, deconvolution, and approximate entropy (ApEn) analyses.
Results. GH area, total secretion, and mean concentration during the free-running night was lower in the SO and 00 groups verses the SS and NL groups (p < .02, Wilcoxon test). GH mean concentration and total secretion significantly increased in all groups during DEX (overall p < .05) except the SO group, in which ApEn increased (p = .03). Pre- and postbreakfast peak salivary cortisol (p = .004) and area under the curve (p = .03) was greatest in the SS group.
Baseline leptin (11:00 Pm) was significantly higher in the SO, 00, and SS groups verses the NL group (p = .01). Appendicular skeletal muscle mass was independently and negatively correlated with leptin in all groups, even after adjusting for percentage body fat (p = .001).
Conclusions. In the presence of obesity, GH secretion was depressed with a blunted and Selleck Bleomycin disorderly response to oral glucocorticoid suppression in SO participants. Sarcopenic participants had concomitantly elevated leptin and cortisol relative to their low body fat mass. Complex or dysregulated neuroendocrine feedback systems appear to be operating in elderly persons with specific Mocetinostat nmr body composition phenotypes.”
“OBJECTIVE: This study assessed the neuropsychological outcome of patients after surgical treatment for third ventricle brain tumors. Neuropsychological consequences of surgical intervention can have a major impact
on patients’ quality of life and therefore have important implications for treatment planning.
METHODS: A retrospective analysis of 33 patients’ neuropsychological data was performed. All patients received a comprehensive neuropsychological evaluation after treatment for a primary brain tumor in the third ventricular region. Twenty-six patients underwent surgery, 14 via the transcallosal approach and 12 via a subfrontal, left transcortical, right pterional, or infratentorial supracerebellar approach. Seven patients were not treated by surgical intervention.
RESULTS: There was a significantly elevated frequency of cognitive impairment relative to normative values in memory, executive functioning, and fine manual speed and dexterity.