Based on these past studies, many thermogenic supplements are successful

Mocetinostat nmr at increasing energy YH25448 ic50 expenditure, but varying doses and combinations of ingredients may cause different cardiovascular and mood state side effects. Further product-specific research on thermogenic aids is needed to determine levels of effectiveness and safety for consumers. The purpose of this study was to evaluate the effects of a commercially available thermogenic dietary supplement on energy expenditure, reported measures of alertness, focus, energy, concentration, fatigue, and hunger, as well as the general tolerance and safety of the supplement based on ECG and hemodynamic responses when taken by healthy, active, young adults. Methods Participants Six males and six females (mean ± SD; age: 22.50 ± 3.22 years; weight: 76.94 ± 14.78 kg; body fat: 22.7 ± 9.5%) volunteered for the study conducted in the Human Performance Lab (HPL) at the University of Mary Hardin-Baylor in Belton,

Texas. Participants were required to be apparently healthy, physically active (regularly participating in exercise for the previous 12 months), moderate caffeine users (<200 mg/day), and were excluded from the study if they had any known metabolic disorders, were sensitive to caffeine, had a history of pulmonary disease, hypertension, TEW-7197 datasheet liver or kidney disease, musculoskeletal or neuromuscular disease, neurological disease, autoimmune disease, or any cancers, peptic ulcers, or anemia. Taking certain medications, including those for heart, pulmonary, thyroid, anti-hyperlipidemic, hypoglycemic, anti-hypertensive, endocrinologic, psychotropic, neuromuscular, neurological, or androgenic conditions, as well as a family history of heart problems,

high blood pressure, and/or stroke, and being pregnant or breastfeeding were also factors for exclusion. Trained lab assistants screened and examined participants as well as obtained a complete medical history to determine if each participant met the qualification standards. Participants reported the number of caffeinated beverages (coffee, tea, soft drink, energy drink, etc.), caffeine containing medications (NoDoz, Vivarin, etc.) and caffeine containing foods (candy, chocolate ice Megestrol Acetate cream, etc.) as well as the serving size (8 oz., 5 oz., etc.) of each reported caffeinated product they consumed per week on average. Average caffeine consumption was determined to be 176.59 ± 86.63 mg/day. Volunteers were required to report any previous or current use of nutritional supplements, prescription and non-prescription medications. Participants were instructed to not change their nutritional supplement/medication intake over the course of the study and to report any changes to lab personnel. Instruments Anthropometric measures Body composition was determined with the use of the Discovery QDR Dual-Energy X-ray Absorptiometry (DEXA) machine (Hologic, Inc., Bedford, MA).