Assessment was by clinical examination aided by the use of hand held Doppler. In the absence of facilities

for emergency contrast angiography at the National Hospital at the time, decisions on surgical exploration and repair were entirely clinical, based on distal ischaemia, pulsatile bleeding, expanding haematoma, palpable thrill or bruit. However in patients presenting with no immediate threat to life or limb such as those with suspected pseudoaneurysms, arterial duplex scanning or angiography was performed before intervention. When ever a vascular injury presented with limb threatening ischaemia, the decision to proceed with vascular Erismodegib mw repair as opposed to primary amputation was based on distal muscle NSC23766 price viability. This was either clinically evident viz. intact toe or ankle movements, or in instances

where such FAK inhibitor movements were absent or other injuries precluded such testing, open fasciotomy and observation of the contractile response of muscle to direct stimulation was used. Limbs with non-contractile muscle in up to two compartments were considered for revascularization while those with more non contractile muscle were recommended primary amputation in view of the high risk for reperfusion injury and poor functional outcome thereafter. The other considerations prior to vascular repair were the mangled extremity severity score (MESS) score [5] and severity of associated nerve and bone injuries. Operative exploration of injured vessels was performed via standard incisions and distal and Ribonucleotide reductase proximal control was obtained. Inflow and backflow were assessed and we routinely passed an embolectomy catheter to proximal and distal segments to perform thrombectomy followed by the flushing of the distal segment with heparinised saline. This was followed by definitive repair. Direct end to end anastomosis was performed if approximation of debrided arterial ends were free of tension. When this was not possible, interposition vein grafting, using autologous

reversed long saphenous vein from the contra- lateral limb, was done. A synthetic graft was used only once for an extra anatomical bypass in the case of an external iliac artery injury. Where venous injury was present, attempt at repair was only made in the case of the axillary, femoral and popliteal veins using either direct repair or vein graft techniques. Other venous injuries were ligated. Where there were associated bone injuries, orthopaedic fixation followed vascular repair in order to minimize ischaemia time. Nerve injuries identified at the time of surgery were repaired primarily. Postoperatively the patients were maintained on intravenous prophylactic antibiotics and venous thromboprophylaxis with low molecular weight heparins in the case of lower limb injuries. Results Demographics Seventy patients with 81 vascular injuries are evaluated in this report of whom 67 (96%) were males. The mean age was 31.2 years (Range 9- 72) with 75% being less than 40.