Concomitant prednisolone, azathioprine and 5-aminosalicylic acid was administered to 37, 61 and 68 subjects, respectively. Previous treatments included prednisolone in 40 subjects, granulocyte–monocyte adsorptive apheresis in 68 and calcineurin inhibitor (cyclosporin

selleck products or tacrolimus) treatment in 33. The 1-, 3-, and 5-year cumulative noncolectomy rates were 75%, 70%, and 65%, respectively. Multivariate Cox regression analysis revealed that previous treatment with calcineurin inhibitors was the background factor that significantly decreased the cumulative noncolectomy rate (hazards ratio, 5.406; 95% confidence interval, 1.732–16.871; P = 0.004). Conclusion: This retrospective study revealed satisfactory long-term outcomes

of IFX treatment in Japanese patients with refractory UC. Previous treatment with calcineurin find more inhibitors may be a poor prognostic factor for patients who undergo IFX treatment for refractory ulcerative colitis. Key Word(s): 1. ulcerative colitis; 2. infliximab; Presenting Author: SOPHIA ZAMORAMEJIA ZAMORA Additional Authors: EULENIA NOLASCORASCO NOLASCO Corresponding Author: SOPHIA ZAMORAMEJIA ZAMORA Affiliations: Manila Doctors Hospital Objective: The data in inflammatory bowel disease (IBD) in the Philippines is still lacking. This study aims to describe the cumulative incidence, clinicopathologic and endoscopic features of patients with IBD in Manila Doctors Hospital (MDH), a tertiary hospital in

the Philippines from 2007 to 2011. Methods: This is a descriptive study involving allpatients diagnosed with IBD in MDH based on clinical, endoscopic or pathologic features with negative TB-PCR results. Results: Sixteen patients were diagnosed with IBD. Nine patients, 56.25% had Ulcerative Colitis (UC),7 patients, 43.25% had Crohn’s Disease (CD) with a UC:CD ratio of 1.28:1. The cumulative incidence was 9.78 new cases per 100,000. IBD has equal male and female distribution. The peak incidence of both CD and UC was between 31 to 40 years old. The most common presentingsymptom was diarrhea, 57.14% in CD while LGIB, 67% in UC. The most common endoscopic findingswere ulcers and nodular/cobblestone mucosa, 71.4% in CD while erythematous Rutecarpine mucosa, 88.9%in UC. The localization of Crohn’s disease was mostly colonic, 57% followed by ileocolonic, 43%. All patients with CD had inflammatory or ulcerating pattern. UC commonly involves theleft side of the colon. The most frequent histopathology result was chronic activecolitis. Conclusion: There is an increasing trend in the incidenceof IBD in MDH from 2007 to 2011. The most common presenting symptom was diarrhea in CD while LGIB in UC. The most common endoscopic findings in CD were ulcers and nodular/cobblestone mucosa while erythematous mucosa in UC patients. Chronic active colitiswas the most frequent histopathology findings. Key Word(s): 1. IBD; 2. Ulcerative Colitis; 3. Crohn’s Disease; 4.